Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury
M Ueda, H Iwasaki, S Wang, E Murata, KYT Poon… - …, 2014 - pubs.asahq.org
Background: Burn injury causes nociceptive behaviors, and inflammation-related pathologic
pain can lead to glial cell activation. This study tested the hypothesis that burn injury
activates glial cells, and cannabinoid receptor 1 (CB1R) antagonist, AM251, will decrease
burn pain. Methods: Anesthetized rats received 0.75-cm2 third-degree burn on dorsal hind
paw. Vehicle or AM251 30 μg intrathecally (older rats, n= 6 per group) or, either vehicle, 0.1
or 1.0 mg/kg intraperitoneally (younger rats, n= 6 per group), started immediate postburn …
pain can lead to glial cell activation. This study tested the hypothesis that burn injury
activates glial cells, and cannabinoid receptor 1 (CB1R) antagonist, AM251, will decrease
burn pain. Methods: Anesthetized rats received 0.75-cm2 third-degree burn on dorsal hind
paw. Vehicle or AM251 30 μg intrathecally (older rats, n= 6 per group) or, either vehicle, 0.1
or 1.0 mg/kg intraperitoneally (younger rats, n= 6 per group), started immediate postburn …
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